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Natural Extracts and Endogenous Antioxidants Certain natural agents rely on intrinsic systemic absorption or direct application, though their efficacy is often limited by rapid metabolism

In addition to their weight loss benefits, these drugs also act through gut-brain signaling and central nervous system pathways involved in appetite, reward, and feeding behavior, although the extent to which individual agents cross the blood-brain barrier remains an active area of investigation

They include both GHRPs and other compounds that trigger hormone release

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