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NICE technology appraisals TA875 (semaglutide 2.4mg/Wegovy) and TA664 (liraglutide 3mg/Saxenda) support their use specifically for weight management in adults within specialist weight management services

The LEADER trial showed that liraglutide reduced the risk of major cardiovascular events in people with type 2 diabetes.[4] Soon after, SUSTAIN-6 demonstrated similar benefits with semaglutide.[5] Then came REWIND, which suggested that cardiovascular protection could extend even to patients without established cardiovascular disease.[6] The SELECT trial made headlines because it showed cardiovascular benefits in people with overweight or obesity who did not have diabetes, a finding that challenged long-held assumptions about who might benefit from these medicines.[7] Most recently, an international trial called SOUL, which tested an oral form of semaglutide, included 788 Indian patients across 32 centres

Creatine monohydrate Creatine is one of the most researched tools for muscle preservation

However, there isnt much additional information on the companys website explaining what the supplement is actually designed to do

Novo also created an oral formulation of semaglutide (Rybelsus), which was also approved for T2D