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PMID: 31790002

Why GLP-1 Medications Are Prescribed GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide are approved for: Adults with a body mass index (BMI) of 30 or greater Adults with a BMI of 27 or greater with at least one weight-related condition such as hypertension, type 2 diabetes, or high cholesterol These medications mimic the GLP-1 hormone, which helps regulate appetite, glucose levels, and insulin secretion

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doi: 10.1371/journal.pone.0124000 50 ZimtaA-ACenariuDIrimieAMagdoLNabaviSMAtanasovAGet al

However, ethical considerations, external validity limitations, challenges in double-blinding, and interference from internal and external factors, coupled with inadequate statistical power and significant financial/temporal requirements, have hampered the feasibility of conducting RCTs