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There are a couple of possible mechanisms for this

In autoimmune hemolytic anemia, reduced CD47 expression promotes red blood cell destruction, whereas in cancer, elevated CD47 levels enable tumor cells to evade immune surveillance (48)

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In addition, the absence of the P53 tumor suppressor gene can obstruct Gln utilization by decreasing GLS2 levels inside cells and boosting ROS levels (68)

Acknowledgements We would like to thank Anne de Jong (University of Groningen) for technical support in the use of T-Rex platform, and Ana Mara lvarez (University of Mlaga) for helping in biofilm experiments