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Most experts recommend long-term or indefinite use, transitioning to a maintenance dose rather than stopping completely, combined with sustained lifestyle changes

High circulating IGF-1 levels have been positively correlated with bad prognosis in patients undergoing endocrine therapy [28], while another study found that high serum IGF-1 is associated with increased all-cause mortality in a cohort of women with established breast malignancy [29]

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Our results showed that Ex-4 increased visfatin secretion to the culture medium and intracellular NAMPT level