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Study Groups Four groups were established according to which glucose-lowering agents were prescribed independently of other antidiabetic drugs concurrently prescribed: (a) all GLP-1RA users (GLP-1RA group), (b) SGLT2 inhibitor users with no GLP-1RA prescription (SGLT2i group), (c) insulin users with no GLP-1RA or SGLT2i prescriptions (insulin group) and (d) users of other glucose-lowering agents (miscellany group) (Fig

Briefly, 0.5 mg of labeling dye was dissolved in 50 l DMSO and was slowly added to 1 ml of protein (10 mg/ml) in 0.1 M sodium bicarbonate buffer (pH 8.3)

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The use of cyclodextrins in pharmaceutical formulations or compositions is well known in the art as cyclodextrins and cyclodextrin derivatives are often used to improve the solubility of a drug