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Furthermore, a benzisoxazole derivative, designed through a scaffold hopping approach from FAA, displayed improved isoform selectivity as an AKR1C3 inhibitor over AKR1C1

The activation of the Janus kinase 2 (JAK2) signaling pathway, a downstream component of the growth hormone receptor, further supports this mechanism

This helps the mitochondria (the powerhouses of the cell) to produce cell energy effectively and the cells to maintain a healthy metabolism

Este enfoque permite reducir la demanda sobre el sistema antioxidante, favoreciendo un entorno en el que el organismo puede funcionar con mayor eficiencia