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When functioning properly, this sphincter opens to allow food passage into the stomach, then closes tightly to prevent acidic contents from traveling upward

If considering visual documentation, be sure to compare progress under consistent lighting, angles, and timelines

After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs