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The resulting particles were subjected to non-uniform 3D refinement, followed by a final local Euler angle local refinement to generate the final consensus maps from which the -helical domain (AHD) of the G s protein and the detergent micelle were masked out
Treatment with PHA665752, a second generation of the highly selective c-MET inhibitor, causes inactivation of c-MET, leading to the inactivation of AKT and downstream signaling of molecules FOXO1 and GSK3 in DLBCL cell lines
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