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While glutathione is generally considered well-tolerated, some individuals may experience: Discomfort at the injection site Digestive changes such as bloating or cramping Headaches or temporary fatigue Rare allergic reactions Excessively high doses, especially when administered too frequently, may interfere with natural antioxidant regulation

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Redox control of cysteine biosynthesis Redox regulation at the level of the first step catalyzed by ATP sulfurylases In Arabidopsis thaliana , four genes encode plastid-located ATP sulfurylases (ATPS14) with ATPS2 being additionally expressed in the cytosol (Bohrer et al., 2015)