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SGLT2 inhibitors when used as an add-on therapy to metformin, insulin, thiazolidinediones, DPP-4 inhibitors, GLP-1 RAs, sulfonylureas, or metformin DPP-4 inhibitor were similarly effective in reducing A1c levels as when used in monotherapy (22,139)

For postpartum women with insulin resistance, PCOS, or gestational diabetes that persists after delivery, metformin may serve double duty by managing blood sugar and supporting weight loss