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41 (5), 334344 (2012) L.M

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However, in the presence of constant pro-angiogenic signaling in the tumor, the newly formed vascular networks may fail to mature and prune, the division into arterioles, capillaries and venules may be lacking, vessel caliber size can be markedly heterogeneous and blood flow through the poorly organized and malformed vessels can be chaotic [82, 83]