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Subsequent work by Sun and colleagues in the APP/PS1 mouse model identified downstream PI3K/AKT pathway activation as a major component of the mechanism, with the PI3K inhibitor wortmannin reversing Dihexas anti-inflammatory and anti-apoptotic effects [5]

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Recent research suggests that reduced glutathione may be an even more effective antioxidant than vitamins C and E, and it is considered the master antioxidant.