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The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimers, the study found

in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )

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Of note, the effect of G49 plus GCGRant regarding body weight loss and visceral adiposity was in line with the effect of Fc-GLP1 (Fig