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When sitagliptin was used in combination with insulin or insulin secretagogues (e.g., sulfonylurea), medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo used in combination with a sulfonylurea or with insulin

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leuprolide acetate (Lupron)) or GnRH-antagonists (e.g

You still rotate sites between injections to prevent lipodystrophy