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In these studies, many side effects were recorded, especially those linked to the stomach, like nausea and vomiting

For the primary composite endpoint of myocardial infarction, stroke or all-cause mortality, benchmarking identified high agreement between the reference trials and their emulations for all individual endpoints except for all-cause mortality in SUSTAIN-6, informing subsequent analyses

Instead, we say as long as it makes sense and engage in shared decision-making with our patients about what that means for them

To reflect the therapeutic intent and the need for standardised macronutrient targets, the term very-lowcalorie ketogenic diet has been recently revised and replaced with very-lowenergy ketogenic therapy (VLEKT), as proposed by the KetoNut expert panel of the Italian Society of Nutraceuticals (SINut) and the Italian Association of Dietetics and Clinical Nutrition (ADI) [106]