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One suggested practice to managing GI AEs is the Three Es method, which comprises 1) education and explanation, 2) escalation to an appropriate dose, and 3) effective management of GI AEs

DOSAGE & ADMINISTRATION General Regardless of the quantity of acetaminophen reported to have been ingested, administer acetylcysteine (acetylcysteine) immediately if 24 hours or less have elapsed from the reported time of ingestion of an overdose of acetaminophen