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A direct comparison of P5 with the reference peptide Ex4 revealed that G-protein signalling downstream of GLP-1R activation in the absence of -arrestin signalling is sufficient to correct hyperglycaemia, improve insulin sensitivity, preserve pancreatic islet integrity and improve liver steatosis

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3.4 Early PsA and future research directions Despite the promising metabolic and immunomodulatory effects observed in PsO, the role of GLP-1RAs in PsA, particularly in its early stages, remains largely unexplored

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Detection was performed using the Dako EnVision + Dual Link System-HRP DAB + (#K4065, Dako/Agilent Technologies, Santa Clara, CA, USA)