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These include several members of the Ruminococcus, Lachnoclostridium , and the Coprococcus genera (all members of the Firmicutes phylum), Akkermansia muciniphila (Verrucomicrobia phylum), and Bifidobacteria (Actinobacteria phylum)

Tirzepatide creates a potential path to corticosteroid reduction through two mechanisms

Reactive astrogliosis and subsequent Nf-B activation downregulate Excitatory amino-acid Transporter 2 (EAAT2), increasing extracellular glutamate levels [22]

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