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In fact, the vascular endothelium grows in the body as a monolayer of cells lining the inner surface of blood vessels within a 3D microenvironment supported by collagen and proteoglycan ECM [241, 242]

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57,186 Alterations in gut microbiota composition, compromised intestinal barrier integrity, and abnormal translocation of microbial metabolites allow endotoxins, such as LPS, to reach the liver via the portal circulation