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The clinical criteria for medical review are attached

10.3390/ijms21239330 52 PerovicD.KolencD.BilicV.SomunN.DrmicD.ElabjerE.et al (2019)

Furthermore, it may not be advantageous to ubiquitously use a potent transcriptional activator in CRISPRa as over-activation of some genes may induce unwanted effects

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My Functioinal medicine doc thinks that this may just be a stress response