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GH-Axis Side Effects Are Biologically Plausible Because CJC-1295 is designed to increase GH-axis signaling, GH-related effects such as fluid retention, edema, joint discomfort, paresthesias, and carpal-tunnel-like symptoms are relevant safety endpoints, even when not proven specifically for every form of CJC-1295

Immunohistochemical observations on spinal tissue innervation: a review of hypothetical mechanisms of back pain

This mutant can still synthesize glutathione, but is not able to produce the inner membrane ABC-transporter CydDC that transports glutathione from the cytosol into the periplasm and hence suffers from reduced periplasmic glutathione levels (Mironov et al., 2020

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10.1016/j.jacc.2014.05.027 18