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Functional readouts of ovarian function and fertility were from 8 weeks (56 days) following chemotherapy, by comparison, the minimum period needed for primordial follicles to develop to the antral stage or ovulation in mice has been estimated from between 20 days (Pedersen, 1970), 42 days (Oakberg, 1979) to 47 days (Zheng et al, 2014), with a recent estimate of 1416 days for the primary follicle transition (Richard et al, 2023)
Although NAC has not been tested in any in vivo experiments after IR yet, this study deduced the possible roles of NAC in delaying RISNHL progression via oxidative stress regulation based on the pathological damage to the inner ear after IR
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