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Glucagon-like peptide-1 receptor analogs (GLP-1RAs) intake associates with lower serum TMAO concentration in MetaCardis T2D participants Given the strong bidirectional connection we uncovered between serum TMAO and eGFR, we hypothesized that use of reno-protective medication could be linked with lower circulating TMAO

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In a study, researchers used a GIP receptor antagonist antibody (GIPRAb) and a GLP- 1 receptor agonist to target both pathways [81]

In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin

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