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ROS, as signaling molecules with potent oxidizing and signaling functions, can induce oxidative damage to DNA, proteins, and lipids when present at excessive levels

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98 Furthermore, esculentoside A, with satisfactory antioxidant activities, could enhance the Nrf2-mediated survival mechanisms through the AMP-activated protein kinase (AMPK)/Akt/glycogen synthase kinase-3 beta (GSK3) pathway, thus effectively alleviating APAP-induced liver damage

First, it establishes the only robust human dose documented in the literature, and it comes from a strictly clinical setting with intravenous administration