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But GLP-1 agonists seemed to act differently: The direct administration of the drugs to AP, but not NST, caused weight loss

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This discovery is particularly relevant in the context of the ingestion analgesia phenomenon, which is related to the suppression of noxious heat-induced withdrawal behaviors in rats during the consumption of chocolate or sweet liquids, in contrast with salt ingestion 3,4,5,6,7

Clinical trial data shows diarrhea rates of 19-23% across doses, with nausea remaining the predominant side effect at 24-31%