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Molecular Mechanisms Entraining and Modifying Central and Cellular Circadian Clocks Photoentrainment of the central circadian clock occurs primarily via light signals to intrinsically photosensitive retinal ganglion cells (ipRGCs) that depolarize and project through a monosynaptic neuronal pathway known as the retinohypothalamic tract (RHT) to the suprachiasmatic nucleus (SCN)