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Some oxidase enzymes can directly generate the hydrogen peroxide radical

October 19, 2023

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In a 12-week, randomized, placebo-controlled trial in which 50,000 IUs (1,250 mcg) vitamin D was given weekly to 30 overweight women (age 1849) with PCOS and vitamin D deficiency, supplementation led to reduced unwanted hair growth and male hormone levels

This intracellular conversion has been confirmed pharmacokinetically: in a peer-reviewed human bioavailability crossover trial, SAG was undetectable in plasma following oral administration because rapid deacetylation occurs before or immediately upon systemic entry meaning the entire SAG load is converted to GSH before reaching blood circulation