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10.1111/cen.14586 83 SmitsM

In addition, A has a tertiary structure similar to that of insulin, peripheral A acts as a negative regulator of insulin secretion, and there can be interactions between A and insulin signaling (You et al., 2022)

Curves were coloured based on the same criteria as in Fig

Stress Suppresses GLP-1 (The Cortisol Cravings Loop) Cortisol decreases natural GLP-1 by: reducing SCFA-producing bacteria increasing inflammation flattening the circadian rhythm damaging mucosal integrity destabilizing serotonin and appetite signals This leads to: Stress cortisol low GLP-1 cravings overeating belly fat Reference Stress & Eating Behavior (Annual Review of Psychology, 2019) 7

Injectable GHK-Cu, by contrast, has far less clinical validation for cosmetic purposes