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An herbal intervention using Drynaria fortunei was found to suppress the NLRP3 inflammasome and downstream cytokines via the Sirtuin 1 (SIRT1)/Notch1 signaling pathway, indicating a potential anti-inflammatory bone-protective mechanism ( Notably, 18F-sodium fluoride positron emission tomography (18F-NaF PET) imaging offers a non-invasive method for assessing vertebral bone turnover