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ASHWOOD-SMITH, M.J., TREVINO, J., & RING, R

The tissue-specific, context-dependent nature of palmatine s effect on cell death, being pro-apoptotic in cancer cells and anti-apoptotic in hepatocytes, further underscores its role as a fine-tuner of apoptotic signaling networks 85

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Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation