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Ligand engagement may preferentially activate cAMP or -arrestin pathways, each of which can variably suppress, stimulate, or fail to influence tumor growth depending on the specific tumor microenvironment [512, 513]

People on GLP-1s aren't just eating less

Patients combining GLP-1 therapy with insulin or sulfonylureas face elevated hypoglycemia risk

Novel uses in unconventional areas such as neurodegenerative conditions, non-alcoholic steatohepatitis (NASH), and cardiovascular disease prevention may enhance the therapeutic potential of these medicines

One key hurdle lies in their contrasting effects on glucose metabolism