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Side Effects and Tolerability: What to Expect Both medications share common side effects, primarily gastrointestinal symptoms like nausea, constipation, and reduced appetite during the initial weeks of therapy

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If you have not yet reached the maximum dose, escalation often restarts weight loss

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[1] Contact your GP or NHS 111 if: Gastrointestinal side effects persist beyond the first few weeks or worsen over time Diarrhoea persists for more than a few days or is accompanied by fever Constipation becomes severe or does not respond to dietary measures and over-the-counter remedies You experience unexplained weight loss beyond expected therapeutic effects Symptoms significantly impact your quality of life or ability to maintain nutrition You have concerns about any new or unusual symptoms Patients with known diverticular disease should maintain regular contact with their healthcare team and report any changes in bowel habits or abdominal symptoms promptly