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#BipolarDisorder #Neuropsychopharmacology #DrugDevelopment #LongActingInjectables #FDAApproval Source: Kane, J

10.14309/ajg.0000000000000501 77 PoutanenS

GLP-1 medications are approved for adults who have a body mass index (BMI) of 30 or higher, or a BMI of at least 27 plus a weight-related medical condition, such as the following: Type 2 diabetes High blood pressure High cholesterol Obstructive sleep apnea Cardiovascular disease that increases the risk of heart attack or stroke MASH, or metabolic dysfunctionassociated steatohepatitis, a form of liver inflammation Avlin Imaeda, MD, PhD, a Yale Medicine gastroenterologist who is board-certified in obesity medicine, notes that qualifying for the medication based on heart disease aloneoften necessary for insurance coveragecan be challenging

(iii) The abundance of Gammaproteobacteria in stool and LPS in plasma were associated with increased concentrations of TMAO in CVID, furthermore bacterial genes CntA and CutC encoding TMA producing enzymes were more abundant in the gut microbiota of CVID patients than in controls

& Mermelstein, R