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HoloTC concentrations followed a similar trend, with the loading dose regimen reaching a median of 300 pmol/L initially, then decreasing to 184 pmol/L at 90 days

This clinical trial history provides access to a published pharmacokinetic and safety dataset, including human tolerability data that is unusual for a research-stage metabolic peptide

While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

Murray Johns