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On the Q4 call, Chief Scientific Officer Dr

Research shows that low B12 levels are associated with increased body fat, disrupted fat processing and insulin resistance, highlighting its role in maintaining metabolic balance

For example, damage-associated molecular patterns (DAMPs) or KRAS G12D proteins released from ferroptotic cells can be packaged into exosomes and internalized by macrophages, transforming them into the M2-like phenotype and leading to an immunosuppressive environment [118]

Understanding their mechanism of action provides a framework for optimizing efficacy, minimizing side effects, and expanding applications beyond diabetes to include other areas such as the treatment of obesity, cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), and even neurodegeneration

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