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Serious adverse events: Higher doses of tirzepatide are associated with a higher rate of serious side effects

Among patients who experienced an early cardiovascular event, those treated with semaglutide had approximately 40% fewer major events at both 3 and 6 months compared to those receiving a placebo, often before most had reached the full target dose

Some users report feeling full sooner and having less interest in snacking

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Market cap gains far exceed historical trends: In an equivalent time period prior to the launch of their GLP-1 products, the combined market cap gains for Novo Nordisk and Eli Lilly was significantly lower at $197 billion3.5x less than the gains realized after the introduction of these products