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TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

For two years, I told myself Id make the appointment to learn about my hormone health, but I never did because I thought I could try managing the weight issues and PCOS symptoms on my ownuntil last August when I reached my highest weight ever

At higher doses, some people experienced more intense digestive side effects, and in a larger phase 3 trial, about 12 to 18% of people stopped treatment because of side effects

About this article Cite this article Zhang, ML., Wu, HT., Chen, WJ

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