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It should be combined with lifestyle modifications such as following a well-balanced diet, regular exercise and/or medication, if needed. Advertisement Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more

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5 Exercise as a modulator of musclevasculature interactions 5.1 Exercise-induced signaling pathways improving endothelial and muscle function Exercise constitutes a robust, pleiotropic stimulus that orchestrates adaptive responses in both skeletal muscle and the vascular endothelium, thereby facilitating the restoration and preservation of the musclevasculature axis, which tends to deteriorate with advancing age