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7 In pancreatic -cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1 pathway, facilitating glycolysis and insulin release
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Use multiple medications that affect blood sugar, blood pressure, or appetite
Microdosing offers distinct advantages: 1
Clinical evidence from studies like STEP 4 showed that discontinuing semaglutide led to significant weight regain in most participants, suggesting that long-term or indefinite use may be necessary for sustained results
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