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Mering and Minkowski's findings encouraged Gustave-douard Laguesse, a French histologist and pathologist, to theorise in 1893 that the pancreatic islets described by Langerhans produced an endocrine secretion (Hoet)

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Peroxisomal role is also related to the function of both cellular components, namely mitochondria and ER, and therefore their dysfunction causes the production and release of H 2 O 2 in the cellular environment