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Clinical studies All 23 relevant clinical studies for this section focused on the effects of GLP-1RAs on cardiometabolic parameters in people with schizophrenia-spectrum disorders on antipsychotics, apart from a secondary analysis investigating cognitive and mental health outcomes 133 (Table 3 and Extended Data Tables 3 and 4)

doi: 10.1001/jamanetworkopen.2026.2450

It is important to distinguish between a simple medication depot and more serious complications such as lipohypertrophy (fatty lumps from repeated injections in the same site) or injection site abscesses

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The key is working with providers who use certified compounding pharmacies, not fly-by-night operations mixing medications in questionable facilities