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and patients with glutathione-S-transferase M1 (proinflammatory-cytokine producer macrophages) null and M1 and T1 (Type 1 helper CD4 + lymphocytes) double null polymorphisms had increased mortality suggesting that antioxidant therapy becomes fundamental for those patients (109)

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Lactate is also a biomarker of bipolar disorder, as lithium treatment has been found to reverse brain lactate accumulation in patients [200]

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