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An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)

10.1155/2021/2915019 43 LiuC.YanQ.GaoC.LinL.WeiJ

Selenium Selenium is an essential cofactor for key enzymes in cellular metabolism, including antioxidant enzymes thioredoxin reductase (TrxR), glutathione peroxidase (GPx), iodothyronine deiodinases (DIOs), and selenoprotein P, all crucial for a correct thyroid function [63, 64]