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These findings align with our plasma biomarker analyses demonstrating reduced plasma levels of the cytokines tumour necrosis factor and MCP-1 in CNS GIPR KO mice, as well as existing literature showing that GLP-1R agonists targeted to CNS GLP-1R have anti-inflammatory effects 20

10.1124/pr.110.002832 Pharmacol

GLP-1 & Muscle Loss: Do Semaglutide or Tirzepatide Cause Muscle Wasting

152 In healthy humans, pancreatic polypeptide has been shown to weakly increase basal insulin secretion by unknown mechanisms but it does not seem to have any effect on GSIS

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