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Glucose oxidation in the brain requires certain micronutrients as cofactors

Very high GGT, especially in combination with raised ALP, bilirubin or symptoms such as jaundice, dark urine, pale stools, severe abdominal pain or unexplained weight loss, needs urgent medical review to rule out bile duct obstruction, gallstones or more serious liver disease

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As a single-center retrospective analysis, it may be subject to selection bias, and conclusions should be validated in large-scale multicenter prospective studies

Pre-treatment samples obtained at visit 1 were also compared to samples obtained at visits 24 during biologically and clinical effective administration of NAC at doses of 2.4 and 4.8 g/day by ANCOVA