The main differences between the two peptides are the following: Development and Approval: Semaglutide was developed later (2010) than liraglutide, and it also received FDA approval much more recently for type 2 diabetes treatment (2017), cardiovascular risk reduction in diabetes (2021) and overweight and obesity management in adults (2021) and adolescents (2023)
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There was an increased number of thyroid cancers in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) clinical trial evaluating liraglutide versus placebo, but the risk did not reach statistical significance (hazard ratio [HR] 1.66, 95% CI 0.406.95), as well as in a meta-analysis of 12 other clinical trials with liraglutide (odds ratio [OR] 1.54, 95% CI 0.406.02) (7,8)
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Vitamina C, antioxidante clave que protege las clulas frente al estrs oxidativo y refuerza el sistema inmunitario
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