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The targeted delivery of MK-801 was further emphasized by analysis of the top 20 differentially expressed genes derived from the top five enriched functional terms showing a similar but stronger transcriptional regulation for GLP-1MK-801 in comparison to MK-801 (Fig

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Given the central role of AMPK in coordinating mitophagy, pharmacological modulation of this energy-sensing kinase has emerged as a promising therapeutic strategy for age-related neuronal degeneration