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Semaglutides reduce body weight through distributed activation throughout the brain

Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

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Of the incretin-based therapies, GLP-1 receptor agonists (GLP-1RAs) directly activate receptors, whereas dipeptidyl peptidase 4 (DPP-4) inhibitors exert their action by preventing degradation of endogenous GLP-1 and GIP 7

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