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The GIP activation appears to buffer gastrointestinal distress rather than compound it, which bodes well for real-world adherence

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However, a substantial body of data suggests that GIP resistance can be largely overcome by agents that lower the circulating glucose level, paving the way for the consideration of GIP as an add-on to glucose-lowering therapies, like GLP-1

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Using United States Department of Veterans Affairs databases, an analysis of 175 health outcomes in 215,970 individuals using GLP1-RAs as usual care for type 2 diabetes was compared to individual cohorts who used other common diabetes treatments, such as sulphonylureas, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter-2 inhibitors

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